Human bladder cancers and normal bladder mucosa present the same hot spot of heterozygous chromosome-9 deletion
نویسندگان
چکیده
منابع مشابه
Role of chromosome 9 in human bladder cancer.
The tumors of 20 patients with multifocal primary transitional cell carcinoma of the bladder or lymph node metastases were examined for molecular genetic defects which we have previously found to be present in > 50% of invasive tumors. These included loss of heterozygosity (LOH) of chromosome 9, which occurs in superficial as well as invasive bladder tumors, and LOH of chromosome 17p and p53 mu...
متن کاملA hot spot for p53 mutation in transitional cell carcinoma of the bladder: clues to the etiology of bladder cancer.
Twenty-eight transitional cell carcinomas of the bladder, grade 2 or 3, were analyzed for the presence of p53 mutations. Thirteen tumors were found to contain 14 mutations. These were all base substitution mutations, of which nine were GC-->AT transitions (three at CpG sites). The remaining five mutations were transversions (three GC-->CG, one GC-->TA, and one AT-->TA). Four of the mutations we...
متن کاملNormal Mucosae of Human Urinary Bladder Comparative Study of Plasminogen Activators in Cancers and Updated Version
We have developed a highly sensitive sandwich enzyme immunoassay for determination of urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) antigen levels in extracts of human tissues. We determined antigen levels of PAs in extracts of 31 primary cancers and 15 normal mucosa! tissues of the urinary bladder using this method. U-PA antigen levels in extracts of ...
متن کاملComparative study of plasminogen activators in cancers and normal mucosae of human urinary bladder.
We have developed a highly sensitive sandwich enzyme immunoassay for determination of urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) antigen levels in extracts of human tissues. We determined antigen levels of PAs in extracts of 31 primary cancers and 15 normal mucosal tissues of the urinary bladder using this method. U-PA antigen levels in extracts of ...
متن کاملAge distribution types of bladder cancers and their relationship with opium consumption and smoking
Background: Recognition of the predisposing factors of bladder cancer is very important and provides possible prevention measures. The aim of this study was to investigate the types, distribution of bladder tumors and their relationship with opium consumption and smoking in patients who referred to Shahid Beheshti Hospital, Babol, Iran. Methods: In this case-control study, all patients ...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 1998
ISSN: 0020-7136,1097-0215
DOI: 10.1002/(sici)1097-0215(19980911)77:6<821::aid-ijc3>3.0.co;2-w